Targeting cell cycle regulators in hematologic malignancies
نویسندگان
چکیده
منابع مشابه
Targeting cell cycle regulators in hematologic malignancies
Hematologic malignancies represent the fourth most frequently diagnosed cancer in economically developed countries. In hematologic malignancies normal hematopoiesis is interrupted by uncontrolled growth of a genetically altered stem or progenitor cell (HSPC) that maintains its ability of self-renewal. Cyclin-dependent kinases (CDKs) not only regulate the mammalian cell cycle, but also influence...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2015
ISSN: 2296-634X
DOI: 10.3389/fcell.2015.00016